Search Result

Pathways Recommended:	Stem Cell/Wnt Cell Cycle/DNA Damage

Results for "

cancer cell lines

" in MedChemExpress (MCE) Product Catalog:

By Targets:	BCRP (1) Acyltransferase (2) ADC Antibody (1) ADC Cytotoxin (8) Akt (5) AMPK (5) Anaplastic lymphoma kinase (ALK) (3) Androgen Receptor (6) Antibiotic (5) Apoptosis (118) Arenavirus (1) Aryl Hydrocarbon Receptor (1) ATM/ATR (1) Autophagy (14) Bacterial (7) Bcl-2 Family (12) Bcr-Abl (2) Biochemical Assay Reagents (2) BMX Kinase (1) Btk (2) c-Met/HGFR (6) c-Myc (1) Carbonic Anhydrase (3) Caspase (8) CD3 (1) CDK (17) Checkpoint Kinase (Chk) (2) COX (1) Cytochrome P450 (1) Deubiquitinase (2) Dihydrofolate reductase (DHFR) (2) DNA Alkylator/Crosslinker (2) DNA-PK (1) DNA/RNA Synthesis (1) Drug Metabolite (2) Drug-Linker Conjugates for ADC (2) DYRK (2) E1/E2/E3 Enzyme (1) EGFR (15) Endogenous Metabolite (13) Ephrin Receptor (1) Epigenetic Reader Domain (9) ERK (2) Estrogen Receptor/ERR (15) FAK (2) Fatty Acid Synthase (FASN) (2) Ferroptosis (2) FGFR (4) FLT3 (2) Fluorescent Dye (2) Fungal (6) Glucosidase (1) GLUT (2) Glutaminase (1) HDAC (8) Histone Acetyltransferase (3) Histone Methyltransferase (6) HIV (4) HPV (1) HSP (4) HSV (1) HuR (2) IAP (2) ICMT (3) IGF-1R (1) Insulin Receptor (1) Isocitrate Dehydrogenase (IDH) (1) Isotope-Labeled Compounds (7) Keap1-Nrf2 (3) Lactate Dehydrogenase (2) Ligands for E3 Ligase (1) LIM Kinase (LIMK) (1) Lipoxygenase (1) MAP3K (1) MDM-2/p53 (9) MEK (1) Melanocortin Receptor (1) MicroRNA (1) Microtubule/Tubulin (28) Mitochondrial Metabolism (3) MMP (1) Necroptosis (2) NF-κB (3) Notch (1) Nuclear Factor of activated T Cells (NFAT) (1) Organoid (2) Oxidative Phosphorylation (1) P-glycoprotein (2) p38 MAPK (3) PAI-1 (2) Parasite (4) PARP (3) PD-1/PD-L1 (1) Phosphatase (2) Phosphoglycerate Dehydrogenase (PHGDH) (2) Phospholipase (2) PI3K (2) Pim (3) PKA (2) PKC (2) Polo-like Kinase (PLK) (5) Porcupine (1) Potassium Channel (1) Progesterone Receptor (1) PROTAC Linkers (1) PROTACs (14) Proteasome (2) Proton Pump (1) Raf (2) Ras (1) Reactive Oxygen Species (16) Reverse Transcriptase (4) Ribosomal S6 Kinase (RSK) (1) ROCK (1) ROS Kinase (2) SARS-CoV (2) SHP2 (1) Sirtuin (1) Sodium Channel (4) Src (5) STAT (2) Telomerase (4) TGF-β Receptor (1) Thymidylate Synthase (1) TNF Receptor (2) Toll-like Receptor (TLR) (1) Topoisomerase (13) Trk Receptor (1) TrxR (1) ULK (1) VEGFR (5) Wnt (1) YAP (2) γ-secretase (1)
By Research Areas:	Cancer (368) Cardiovascular Disease (2) Endocrinology (5) Infection (20) Inflammation/Immunology (13) Metabolic Disease (5) Neurological Disease (6)

By Targets:

BCRP (1)

Acyltransferase (2)

ADC Antibody (1)

ADC Cytotoxin (8)

Akt (5)

AMPK (5)

Anaplastic lymphoma kinase (ALK) (3)

Androgen Receptor (6)

Antibiotic (5)

Apoptosis (118)

Arenavirus (1)

Aryl Hydrocarbon Receptor (1)

ATM/ATR (1)

Autophagy (14)

Bacterial (7)

Bcl-2 Family (12)

Bcr-Abl (2)

Biochemical Assay Reagents (2)

BMX Kinase (1)

Btk (2)

c-Met/HGFR (6)

c-Myc (1)

Carbonic Anhydrase (3)

Caspase (8)

CD3 (1)

CDK (17)

Checkpoint Kinase (Chk) (2)

COX (1)

Cytochrome P450 (1)

Deubiquitinase (2)

Dihydrofolate reductase (DHFR) (2)

DNA Alkylator/Crosslinker (2)

DNA-PK (1)

DNA/RNA Synthesis (1)

Drug Metabolite (2)

Drug-Linker Conjugates for ADC (2)

DYRK (2)

E1/E2/E3 Enzyme (1)

EGFR (15)

Endogenous Metabolite (13)

Ephrin Receptor (1)

Epigenetic Reader Domain (9)

ERK (2)

Estrogen Receptor/ERR (15)

FAK (2)

Fatty Acid Synthase (FASN) (2)

Ferroptosis (2)

FGFR (4)

FLT3 (2)

Fluorescent Dye (2)

Fungal (6)

Glucosidase (1)

GLUT (2)

Glutaminase (1)

HDAC (8)

Histone Acetyltransferase (3)

Histone Methyltransferase (6)

HIV (4)

HPV (1)

HSP (4)

HSV (1)

HuR (2)

IAP (2)

ICMT (3)

IGF-1R (1)

Insulin Receptor (1)

Isocitrate Dehydrogenase (IDH) (1)

Isotope-Labeled Compounds (7)

Keap1-Nrf2 (3)

Lactate Dehydrogenase (2)

Ligands for E3 Ligase (1)

LIM Kinase (LIMK) (1)

Lipoxygenase (1)

MAP3K (1)

MDM-2/p53 (9)

MEK (1)

Melanocortin Receptor (1)

MicroRNA (1)

Microtubule/Tubulin (28)

Mitochondrial Metabolism (3)

MMP (1)

Necroptosis (2)

NF-κB (3)

Notch (1)

Nuclear Factor of activated T Cells (NFAT) (1)

Organoid (2)

Oxidative Phosphorylation (1)

P-glycoprotein (2)

p38 MAPK (3)

PAI-1 (2)

Parasite (4)

PARP (3)

PD-1/PD-L1 (1)

Phosphatase (2)

Phosphoglycerate Dehydrogenase (PHGDH) (2)

Phospholipase (2)

PI3K (2)

Pim (3)

PKA (2)

PKC (2)

Polo-like Kinase (PLK) (5)

Porcupine (1)

Potassium Channel (1)

Progesterone Receptor (1)

PROTAC Linkers (1)

PROTACs (14)

Proteasome (2)

Proton Pump (1)

Raf (2)

Ras (1)

Reactive Oxygen Species (16)

Reverse Transcriptase (4)

Ribosomal S6 Kinase (RSK) (1)

ROCK (1)

ROS Kinase (2)

SARS-CoV (2)

SHP2 (1)

Sirtuin (1)

Sodium Channel (4)

Src (5)

STAT (2)

Telomerase (4)

TGF-β Receptor (1)

Thymidylate Synthase (1)

TNF Receptor (2)

Toll-like Receptor (TLR) (1)

Topoisomerase (13)

Trk Receptor (1)

TrxR (1)

ULK (1)

VEGFR (5)

Wnt (1)

YAP (2)

γ-secretase (1)

By Research Areas:

Cancer (368)

Cardiovascular Disease (2)

Endocrinology (5)

Infection (20)

Inflammation/Immunology (13)

Metabolic Disease (5)

Neurological Disease (6)

393

Inhibitors & Agonists

Fluorescent Dye

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: BCRP Itk TOPK NAMPT ALCAM/CD166 GDNF Receptor BCL6 Tim3

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-153356

MRT-2359	Apoptosis	Cancer
MRT-2359 is a potent, orally active and selective GSPT1 depressant (IC₅₀: >30 nM and <300 nM) that specifically induces apoptosis dependent on protein translation. MRT-2359 exhibits significant and preferred anti-proliferative activity in a variety of cancer cell lines, especially MYC-driven cell lines, such as non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) with high expression of N-Myc or L-Myc. MRT-2359 inhibits the growth of drug-resistant NSCLC and SCLC cells, making it suitable for cancer research .

HY-W278944

Antiproliferative agent-15	Others	Cancer
Antiproliferative agent-15 is an anticancer agent. Antiproliferative agent-15 shows antiproliferative activity against human colon (HCT116 and HCT15) and brain (LN-229 and GBM-10) cancer cell lines .

HY-103454B

MPP hydrochloride 5+ Cited Publications	Estrogen Receptor/ERR Apoptosis	Endocrinology Cancer
MPP hydrochloride is a potent and selective ER (estrogen receptor) modulator. MPP hydrochloride induces significant apoptosis in the endometrial cancer and oLE cell lines. MPP hydrochloride reverses the the positive effects of beta-estradiol. MPP hydrochloride has mixed agonist/antagonist action on murine uterine ERalpha in vivo .

HY-114646

TMC-205	Endogenous Metabolite	Cancer
TMC-205 is a natural fungal metabolite with antiproliferative activity against cancer cell lines. TMC-205 is a transcriptional up-regulator of SV40 promoter .

HY-144872

RJ-34	Others	Cancer
RJ-34, an aristolactam analogue, exhibits potent antitumor activities against a broad array of cancer cell lines with GI₅₀ values in the subnanomolar range (GI₅₀ <0.1 nM for A431, MES-SA, MES-SA/DX5, HCT-15, and HCT-15/CLO2 cells) .

HY-163125

BHEPN	VEGFR	Cancer
BHEPN is an inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2). BHEPN has inhibition of VEGFR-2 with an IC₅₀ value of 0.320 μM. BHEPN also exhibits remarkable cytotoxic effects against HepG2 and MCF-7 cancer cell lines, with IC₅₀ values of 0.19 μM and 1.18 μM, respectively. BHEPN can be used for anticancer research .

HY-15160

TAK-960 2 Publications Verification	Polo-like Kinase (PLK)	Cancer
TAK-960 is an orally available, selective inhibitor of polo-like kinase 1 (PLK1), with an IC₅₀ of 0.8 nM. TAK-960 also shows inhibitory activities against PLK2 and PLK3, with IC₅₀s of 16.9 and 50.2 nM, respectively. TAK-960 inhibits proliferation of multiple cancer cell lines and exhibits significant efficacy against multiple tumor xenografts .

HY-15160B

TAK-960 dihydrochloride 2 Publications Verification	Polo-like Kinase (PLK)	Cancer
TAK-960 dihydrochloride is an orally available, selective inhibitor of polo-like kinase 1 (PLK1), with an IC₅₀ of 0.8 nM. TAK-960 dihydrochloride also shows inhibitory activities against PLK2 and PLK3, with IC₅₀s of 16.9 and 50.2 nM, respectively. TAK-960 dihydrochloride inhibits proliferation of multiple cancer cell lines and exhibits significant efficacy against multiple tumor xenografts .

HY-15160A

TAK-960 hydrochloride	Polo-like Kinase (PLK)	Cancer
TAK-960 hydrochloride is an orally available, selective inhibitor of polo-like kinase 1 (PLK1), with an IC₅₀ of 0.8 nM. TAK-960 hydrochloride also shows inhibitory activities against PLK2 and PLK3, with IC₅₀s of 16.9 and 50.2 nM, respectively. TAK-960 hydrochloride inhibits proliferation of multiple cancer cell lines and exhibits significant efficacy against multiple tumor xenografts .

HY-146208

BRD4 Inhibitor-20	Epigenetic Reader Domain	Cancer
BRD4 Inhibitor-20 is a potent orally active bromodomain protein 4 (BRD4) inhibitor. BRD4 Inhibitor-20 has inhibitory activity for BRD4 (BD1) and BRD4 (BD2) with IC₅₀ values of 19 nM and 28 nM, respectively. BRD4 Inhibitor-20 also has anti-proliferation activities in cancer cell lines. BRD4 Inhibitor-20 can be used for the research of kinds of cancer, such as colon cancer .

HY-114402

ARD-69	Androgen Receptor PROTACs	Cancer
ARD-69 (compound 34) is a potent PROTAC androgen receptor degrader. ARD-69 induces degradation of androgen receptor (AR) protein in AR-positive prostate cancer cell lines. ARD-69 suppresses AR-regulated gene expression . ARD-69 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-15160C

TAK-960 monohydrochloride	Polo-like Kinase (PLK)	Cancer
TAK-960 monohydrochloride is an orally available, selective inhibitor of polo-like kinase 1 (PLK1), with an IC₅₀ of 0.8 nM. TAK-960 monohydrochloride also shows inhibitory activities against PLK2 and PLK3, with IC₅₀s of 16.9 and 50.2 nM, respectively. TAK-960 monohydrochloride inhibits proliferation of multiple cancer cell lines and exhibits significant efficacy against multiple tumor xenografts .

HY-101597

NVX-207	Apoptosis	Cancer
NVX-207, a Betulinic acid-derived anti-cancer compound, shows anti-tumor activity (mean IC₅₀=3.5 μM) against various human and canine cell lines. NVX-207-induced apoptosis is associated with activation of the intrinsic apoptotic pathway via cleavage of caspases -9, -3, -7 and of PARP .

HY-N10304

Isodispar B	Apoptosis	Cancer
Isodispar B is an anticancer agent that inhibits the proliferation of nasopharyngeal carcinoma and breast cancer cells and induces cell apoptosis. Isodispar B is cytotoxic to a wide range of cancer cell lines .

HY-133129

MS1943 1 Publications Verification	Histone Methyltransferase Apoptosis	Cancer
MS1943 is a first-in-class, orally bioavailable EZH2 selective degrader, with an IC₅₀ of 120 nM. MS1943 significantly reduces EZH2 protein levels in numerous triple-negative breast cancer (TNBC) and other cancer and noncancerous cell lines. MS1943 effectively blocks proliferation of multiple TNBC and other cancer cell lines .

HY-111761

DIQ3

Others Cancer

DIQ3 is a potent anti-cancer agent, nontoxic to normal human cell lines .

DIQ3	Others	Cancer
DIQ3 is a potent anti-cancer agent, nontoxic to normal human cell lines .

HY-100012

CBR-5884 15+ Cited Publications	Phosphoglycerate Dehydrogenase (PHGDH)	Cancer
CBR-5884 is an active, selective inhibitor of phosphoglycerate dehydrogenase (PHGDH) with an IC₅₀ of 33 μM. CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with high serine biosynthetic activity. CBR-5884 selectively inhibits the proliferation of melanoma and breast cancer lines that have a high propensity for serine synthesis .

HY-19637

SW044248

Topoisomerase Cancer

SW044248 is a non-canonical topoisomerase I inhibitor, and selectively toxic for certain non-small cell lung cancer (NSCLC) cell lines.
HY-123786

NSC745887

Others Cancer

NSC745887 (compound 25) is an anti-cancer agent. NSC745887 exhibits dose-dependent inhibition of proliferation in all 60 cancer cell lines .

SW044248	Topoisomerase	Cancer
SW044248 is a non-canonical topoisomerase I inhibitor, and selectively toxic for certain non-small cell lung cancer (NSCLC) cell lines.

NSC745887	Others	Cancer
NSC745887 (compound 25) is an anti-cancer agent. NSC745887 exhibits dose-dependent inhibition of proliferation in all 60 cancer cell lines .

HY-136910

USP7-IN-7	Deubiquitinase	Cancer
USP7-IN-7 (compound 124) is a USP7 inhibitor with an IC₅₀ value ＜10 nM. USP7-IN-7 shows cytotoxicity against p53-mutant cancer cell lines, p53 wild-type blood cancer and neuroblastoma cell lines with low nanomolar values. USP7-IN-7 can be used for cancer research .

HY-P0121

ReACp53

2 Publications Verification

MDM-2/p53 Cancer

ReACp53 could inhibit p53 amyloid formation and rescue p53 function in cancer cell lines.
HY-N3924

Ganoderiol F

Others Others

Ganoderiol F, a tetracyclic triterpene, is isolated from Ganoderma amboinense and found to induce senescence of cancer cell lines .
HY-116107

AG311

Necroptosis Cancer

AG311 is an anticancer and antimetastatic agent. AG311 induces rapid necrosis in numerous cancer cell lines .

ReACp53 2 Publications Verification	MDM-2/p53	Cancer
ReACp53 could inhibit p53 amyloid formation and rescue p53 function in cancer cell lines.

Ganoderiol F	Others	Others
Ganoderiol F, a tetracyclic triterpene, is isolated from Ganoderma amboinense and found to induce senescence of cancer cell lines .

AG311	Necroptosis	Cancer
AG311 is an anticancer and antimetastatic agent. AG311 induces rapid necrosis in numerous cancer cell lines .

HY-106588

Heptaplatin SKI 2053R	DNA Alkylator/Crosslinker	Cancer
Heptaplatin (SKI 2053R) is a platinum derivative with anticancer activity against various cancer cell lines, including cisplatin-resistant tumor cell lines. SKI-2053R is active in the research of gastric adenocarcinoma and has favorable toxicity profiles .

HY-N0944

(-)-Heraclenol	Others	Cancer
(-)-Heraclenol is a derivative of furocoumarin isolated from Ducrosia anethifolia. (-)-Heraclenol shows antiproliferative and cytotoxic activities on cancer cell lines .

HY-N8718

Izalpinin

Others Others

Izalpinin is a dihydrochalcone with cytotoxic effect against cancer cell lines. Izalpinin can be isolated from the leaves of Muntingia calabura .

Izalpinin	Others	Others
Izalpinin is a dihydrochalcone with cytotoxic effect against cancer cell lines. Izalpinin can be isolated from the leaves of Muntingia calabura .

HY-P99011

Cibisatamab	CD3	Cancer
Cibisatamab (CEA-TCB), a T cell bispecific antibody, binds Carcino-Embryonic Antigen (CEA) on cancer cells and CD3 on T cells. Cibisatamab (CEA-TCB) triggers T cell killing of cancer cell lines expressing moderate to high levels of CEA at the cell surface. Cibisatamab (CEA-TCB) can be used for colorectal cancer research .

HY-108992

Deoxynyboquinone	Apoptosis Reactive Oxygen Species	Cancer
Deoxynyboquinone, an excellent NQO1 substrate, is a potent antineoplastic agent. Deoxynyboquinone induces apoptosis in cancer cell lines. Deoxynyboquinone kills cancer cells through oxidative stress and reactive oxygen species (ROS) formation .

HY-149076

hGAPDH-IN-1	Others	Cancer
hGAPDH-IN-1, a 3-bromo-4,5-dihydroisoxazole derivative, is a specific and potent hGAPDH covalent inhibitor. hGAPDH-IN-1 reduces cancer cell growth in different pancreatic cancer cell lines.

HY-N0162

Luteolin 30+ Cited Publications Luteoline; Luteolol; Digitoflavone	Keap1-Nrf2 Apoptosis Autophagy Endogenous Metabolite	Inflammation/Immunology Cancer
Luteolin (Luteoline), a flavanoid compound, is a potent Nrf2 inhibitor. Luteolin has anti-inflammatory, anti-cancer properties, including the induction of apoptosis and cell cycle arrest, and the inhibition of metastasis and angiogenesis, in several cancer cell lines, including human non-small lung cancer cells .

HY-129156

HS-1793

Apoptosis Cancer

HS-1793 is a Resveratrol (HY-16561) analogue with antitumor activities in a variety of cancer cell lines . HS-1793 induces cell apoptosis .

HS-1793	Apoptosis	Cancer
HS-1793 is a Resveratrol (HY-16561) analogue with antitumor activities in a variety of cancer cell lines . HS-1793 induces cell apoptosis .

HY-W303895

Luteolin monohydrate	Others	Others
Luteolin (monohydrate) is the monohydrate of Luteolin. Luteolin (Luteoline), a flavonoid, is also a potent Nrf2 inhibitor. Luteolin has anti-inflammatory and anticancer properties, induces apoptosis and cell cycle arrest in multiple human cancer cell lines, including non-small lung cancer cells, and inhibits cell metastasis and angiogenesis .

HY-N3119

Paeoniflorigenone	Apoptosis	Cancer
Paeoniflorigenone, isolated as an active ingredient from the root of moutan cortex, induces apoptosis selectively in the cancer cell lines and exhibits antiproliferative effect .

HY-12842

UC-112	IAP Apoptosis	Cancer
UC-112 is a novel potent IAP(Inhibitor of apoptosis) inhibitor; potently inhibit cell growth in two human melanoma (A375 and M14) and two human prostate (PC-3 and DU145) cancer cell lines(IC50=0.7-3.4 uM).

HY-N3057

Pinostrobin chalcone	Others	Cancer
Pinostrobin chalcone is found to be potent natural cytotoxic compounds against MDA-MB-231 and HT-29 colon cancer cell lines(IC₅₀ = 20.42±2.23 and 22.51±0.42 μg/mL) .

HY-13915

NSC348884 2 Publications Verification	Apoptosis	Cancer
NSC348884 is a nucleophosmin (NPM) inhibitor, it disrupts oligomer formation and induces apoptosis, inhibits cell proliferation with IC₅₀s of 1.7-4.0 μM in distinct cancer cell lines. NSC348884 can be used for the research of cancer .

HY-123901

Garcinone E	Apoptosis	Cancer
Garcinone E is a natural xanthone found in the rind of the mangosteen fruit. Garcinone E induces apoptosis and inhibits cancer cell migration. Garcinone E has anticancer effects on different human cancer cell lines, including colorectal, breast, and hepatocellular carcinomas .

HY-160469

INY-05-040	Akt PROTACs	Cancer
INY-05-040 is a AKT degrader that can selectively and quickly degrade all three AKT isoforms. INY-05-040 can inhibit downstream signaling and cell proliferation in 288 cancer cell lines, with anti-cancer activity .

HY-B0114S1

Oxcarbazepine-d4-1 GP 47680-d₄-1	Isotope-Labeled Compounds Sodium Channel Apoptosis	Neurological Disease Cancer
Oxcarbazepine-d₄-1 is deuterium labeled Oxcarbazepine. Oxcarbazepine is a sodium channel blocker[1]. Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines[2]. Anti-cancer and anticonvulsant effects[2][3].

HY-100395

F16	Apoptosis	Cancer
F16 is a potent growth inhibitor of the *neu-overexpressing cells* and also selectively inhibits proliferation of mammary epithelial as well as a variety of mouse mammary tumor and human breast cancer cell lines.

HY-N2445

Flavokawain C 1 Publications Verification	Apoptosis	Cancer
Flavokawain C is a natural chalcone found in Kava root. Flavokawain C exerts cytotoxicity against human cancer cell lines, with an IC₅₀ of 12.75 μM for HCT 116 cells .

HY-155413

Antiproliferative agent-43	Apoptosis	Cancer
Antiproliferative agent-43 (Compound e4 ) has notable cytotoxic effects against cancer cell lines and causes apoptosis by stopping the cell cycle at G1 phase .

HY-10340

Tirbanibulin 5+ Cited Publications KX2-391; KX-01	Src Microtubule/Tubulin	Cancer
Tirbanibulin (KX2-391) is an inhibitor of Src that targets the peptide substrate site of Src, with GI₅₀ of 9-60 nM in cancer cell lines.

HY-10340A

Tirbanibulin dihydrochloride 5+ Cited Publications KX2-391 dihydrochloride; KX-01 dihydrochloride	Src Microtubule/Tubulin	Cancer
Tirbanibulin (dihydrochloride) (KX2-391 (dihydrochloride)) is an inhibitor of Src that targets the peptide substrate site of Src, with GI₅₀ of 9-60 nM in cancer cell lines.

HY-10340B

Tirbanibulin Mesylate 5+ Cited Publications KX2-391 Mesylate; KX01 Mesylate	Src Microtubule/Tubulin	Cancer
Tirbanibulin Mesylate (KX2-391 Mesylate) is an inhibitor of Src that targets the peptide substrate site of Src, with GI₅₀ of 9-60 nM in cancer cell lines.

HY-116896

LY117018	Estrogen Receptor/ERR	Cancer
LY117018, a Raloxifene analog, is a selective estrogen receptor modulator. LY117018 exerts antiproliferative effects on breast cancer cell lines .

HY-136591

Demoxepam	Drug Metabolite	Neurological Disease Cancer
Demoxepam is a major metabolite of Chlordiazepoxide. Demoxepam exhibits cytotoxicity activity against cancer cell lines. Demoxepam has anticonvulsant and anxiolytic effects .

HY-N3968

Goniothalamin GTN; (R)-(+)-Goniothalamin	Apoptosis	Inflammation/Immunology Cancer
Goniothalamin (GTN) is styryllactone with anticancer, anti-inflammatory, immunosuppressive properties. Goniothalamin induces cytotoxicity, DNA damage and apoptosis of a variety of cancer cell lines .

HY-50914

AZD5597

CDK Cancer

AZD5597 is an inhibitor of CDK with an IC₅₀ of 2 nM. AZD5597 has potent anti-proliferative effects against a range of cancer cell lines .

HY-144898

SB-216	Microtubule/Tubulin	Cancer
SB-216 is a potent tubulin polymerization inhibitor. SB-216 shows strong antiproliferative potency in a panel of human cancer cell lines, including melanoma, lung cancer, and breast cancer. SB-216 can be used for cancer research .

Cat. No.	Product Name	Target	Research Area

HY-P0121

ReACp53

2 Publications Verification

MDM-2/p53 Cancer

ReACp53 could inhibit p53 amyloid formation and rescue p53 function in cancer cell lines.

HY-P1940

Maculosin Cyclo(Tyr-Pro)	Peptides	Cancer
Maculosin is a host-specific phytotoxin for spotted knapweed from Alternaria alternata. Maculosin is a quorum-sensing molecule involved in cell-cell communication by Pseudomonas aeruginosa. Maculosin also acts as a signaling molecule regulating virulence gene expression in Lactobacillus reuteri. Maculosin shows antioxidant, anti-cancer and non-toxicity properties. Maculosin shows cytotoxic activity against the human liver cancer cell lines, with an IC₅₀ of 48.90 µg/mL .

HY-P3717

Targefrin	Ephrin Receptor	Cancer
Targefrin is a potent EphA2-targeting agent, acts as an antagonist. Targefrin binds EphA2-LBD with 21 nM dissociation constant and an IC₅₀ value of 10.8 nM. Targefrin induces cellular receptor internalization and degradation in several pancreatic cancer cell lines .

HY-P10224

G7-18NATE	Peptides	Cancer
G7-18NATE is a peptide inhibitor of Grb7. HY-P10224 binds to the Grb7-SH2 domain with micromolar affinity (K_D = 18.1 μM). G7-18NATE inhibits cell proliferation, motility, cell invasion and 3D culture formation in several cancer cell lines .

HY-P5391

LL-37(17-32)	Bacterial	Others
LL-37(17-32) is a biological active peptide. (This peptide is an active segment of LL-37, a peptide derived from the C-terminal domain of human cathelicidin antimicrobial peptide. It has been reported that the LL17-32 peptide exhibits reversal effect on ABCG2-mediated multidrug resistance in cancer cell lines.)

HY-P5327

r8 Bid BH3	Bcl-2 Family	Others
r8 Bid BH3 is a biological active peptide. (The Bid BH3 is a pro-apoptotic member of the 'BH3-only' subset of BCL-2 family proteins that constitute a critical control point in apoptosis. r8BIDBH3 is lethal to human leukemia cell lines that expresse Bcl-2. The Bcl-2 antagonists may have the potential to be efficacious in cancer therapy. Poly-D-arginine (d-isomer as denoted by rrrrrrrr) is fused to the Bid BH3 peptide to facilitate cellular uptake of the peptide.)

Cat. No.	Product Name	Target	Research Area

HY-P99011

Cibisatamab	CD3	Cancer
Cibisatamab (CEA-TCB), a T cell bispecific antibody, binds Carcino-Embryonic Antigen (CEA) on cancer cells and CD3 on T cells. Cibisatamab (CEA-TCB) triggers T cell killing of cancer cell lines expressing moderate to high levels of CEA at the cell surface. Cibisatamab (CEA-TCB) can be used for colorectal cancer research .

HY-P99413

IMAB027 ASP1650	Inhibitory Antibodies	Cancer
IMAB027 (ASP1650) is a specific anti-CLDN6 mAb, while CLDN6 (Claudin 6) is a tight junction membrane protein, aberrantly expressed in various human cancer types, ovarian cancers particularly. IMAB 027 shows anti-tumor activity, and induces apoptosis in CLDN6 ⁺ ovarian and testicular cancer cell lines .

HY-P99361

Enavatuzumab PDL192; ABT-361; Anti-TNFRSF12A/TWEAKR/CD266 Reference Antibody (enavatuzumab)	TNF Receptor	Cancer
Enavatuzumab (PDL192; ABT-361) is a humanized IgG1 monoclonal antibody targeting the receptor of TNF-like weak inducer of apoptosis (TWEAK). TWEAK (Fn14; TNFRSF12A), the natural ligand of the TWEAK receptor (TweakR), stimulates multiple cellular responses. Enavatuzumab induces tumor growth inhibition through direct TweakR signaling and antibody dependent cell-mediated cytotoxicity (ADCC). Enavatuzumab can actively recruits and activates myeloid effectors to kill tumor cells. Enavatuzumab inhibits the growth of various human TweakR-positive cancer cell lines and xenografts in vitro and in vivo .

HY-P990027

Izeltabart	ADC Antibody	Cancer
Izeltabart is a high-affinity humanized antibody targeting ADAM9. Izeltabart can be used as ADC Antibody for site-specific conjugation with Maytansinoid-based DM21-C (a Drug-Linker Conjugates for ADC), to synthesize IMGC936 (Antibody-Drug Conjugates (ADCs)) with strong anti-cancer activity. DM21-C is composed of Maytansinoid (microtubule inhibitor) and a stable tripeptide linker. IMGC936 exhibits cytotoxicity against ADAM9-positive human tumor cell lines and potent antitumor activity in xenograft tumor models .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N3924

Ganoderiol F	Triterpenes Microorganisms Terpenoids Source classification	Others
Ganoderiol F, a tetracyclic triterpene, is isolated from Ganoderma amboinense and found to induce senescence of cancer cell lines .

HY-114646

TMC-205	Alkaloids Microorganisms Classification of Application Fields Source classification Disease Research Fields Indole Alkaloids Cancer	Endogenous Metabolite
TMC-205 is a natural fungal metabolite with antiproliferative activity against cancer cell lines. TMC-205 is a transcriptional up-regulator of SV40 promoter .

HY-N10304

Isodispar B	Structural Classification Lycoris radiata (L’Her.) Herb. Source classification Coumarins Phenylpropanoids Plants Amaryllidaceae	Apoptosis
Isodispar B is an anticancer agent that inhibits the proliferation of nasopharyngeal carcinoma and breast cancer cells and induces cell apoptosis. Isodispar B is cytotoxic to a wide range of cancer cell lines .

HY-N0944

(-)-Heraclenol	Natural Products other families Classification of Application Fields Source classification Plants Disease Research Fields Cancer	Others
(-)-Heraclenol is a derivative of furocoumarin isolated from Ducrosia anethifolia. (-)-Heraclenol shows antiproliferative and cytotoxic activities on cancer cell lines .

HY-N8718

Izalpinin	Source classification Muntingia calabura L. Plants Muntingiaceae	Others
Izalpinin is a dihydrochalcone with cytotoxic effect against cancer cell lines. Izalpinin can be isolated from the leaves of Muntingia calabura .

HY-N0162

Luteolin Maximum Cited Publications 32 Publications Verification Luteoline; Luteolol; Digitoflavone	Structural Classification Classification of Application Fields Flavones Source classification Plants Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids other families Microorganisms Phenols Polyphenols Inflammation/Immunology Disease Research Fields	Keap1-Nrf2 Apoptosis Autophagy Endogenous Metabolite
Luteolin (Luteoline), a flavanoid compound, is a potent Nrf2 inhibitor. Luteolin has anti-inflammatory, anti-cancer properties, including the induction of apoptosis and cell cycle arrest, and the inhibition of metastasis and angiogenesis, in several cancer cell lines, including human non-small lung cancer cells .

HY-N3119

Paeoniflorigenone	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Paeoniaceae Disease Research Fields Cancer Paeonia suffruticosa Andr.	Apoptosis
Paeoniflorigenone, isolated as an active ingredient from the root of moutan cortex, induces apoptosis selectively in the cancer cell lines and exhibits antiproliferative effect .

HY-N3057

Pinostrobin chalcone	Flavonoids Chalcones Classification of Application Fields Leguminosae Source classification Phenols Polyphenols Plants Disease Research Fields Cancer Cajanus cajan (L.) Millsp.	Others
Pinostrobin chalcone is found to be potent natural cytotoxic compounds against MDA-MB-231 and HT-29 colon cancer cell lines(IC₅₀ = 20.42±2.23 and 22.51±0.42 μg/mL) .

HY-123901

Garcinone E	Structural Classification Flavonoids Source classification Guttiferae Garcinia mangostana Linn. Plants Other Flavonoids	Apoptosis
Garcinone E is a natural xanthone found in the rind of the mangosteen fruit. Garcinone E induces apoptosis and inhibits cancer cell migration. Garcinone E has anticancer effects on different human cancer cell lines, including colorectal, breast, and hepatocellular carcinomas .

HY-N2445

Flavokawain C 1 Publications Verification	Chalcones Flavonoids other families Classification of Application Fields Source classification Piper methysticum Forst Phenols Polyphenols Piperaceae Plants Disease Research Fields Cancer	Apoptosis
Flavokawain C is a natural chalcone found in Kava root. Flavokawain C exerts cytotoxicity against human cancer cell lines, with an IC₅₀ of 12.75 μM for HCT 116 cells .

HY-N3968

Goniothalamin GTN; (R)-(+)-Goniothalamin	Structural Classification Natural Products Lythraceae Source classification Plants Lythrum salicaria L.	Apoptosis
Goniothalamin (GTN) is styryllactone with anticancer, anti-inflammatory, immunosuppressive properties. Goniothalamin induces cytotoxicity, DNA damage and apoptosis of a variety of cancer cell lines .

HY-N9507

Picrasidine Q	Alkaloids other families Classification of Application Fields Source classification Quinoline Alkaloids Plants Disease Research Fields Indole Alkaloids Cancer	Apoptosis FGFR
Picrasidine Q, an alkaloid component extracted from Angelica keiskei species, has the capacity of anti-cell transformation and anti-cancer. Picrasidine Q induces cell apoptosis and G1 phase arrest in human esophageal cancer cell lines, and directly inhibits FGFR2 kinase activity .

HY-N10393

Vibsanin A	Structural Classification Natural Products Classification of Application Fields Viburnaceae Source classification Viburnum awabuki K. Koch Plants Disease Research Fields Cancer	PKC HSP
Vibsanin A, a protein kinase C (PKC) activator, exhibits anti-proliferative activity against human cancer cell lines. Vibsanin A is also a HSP90 inhibitor .

HY-129584

Lepidiline B	Structural Classification Alkaloids Other Alkaloids Source classification Plants Brassicaceae Lepidium meyenii Walp.	Others
Lepidiline B is a flavonolignan isolated from the roots of Brassicaceae Lepidium meyenii. Lepidiline B exhibits anti-inflammation activities in human cancer cell lines .

HY-122948

Isogambogenic acid	Flavonoids Guttiferae Plants Garcinia hanburyi Hook. f. Other Flavonoids	Others
Isogambogenic acid is a natural product that can be isolated from Resina Garciniae. Isogambogenic acid has cytotoxicity to cancer cell lines with IC₅₀ values of 0.4327-5.942 μmol/L .

HY-N3210

Nb-Demethylechitamine	Apocynaceae Structural Classification Alkaloids Source classification Plants Indole Alkaloids Alstonia rostrata C. E. C. Fischer	Others
Nb-Demethylechitamine is an alkaloid isolated from the methanol extract of Alstonia rostrata twigs. Nb-Demethylechitamine has in vitro cytotoxic activity against several human cancer cell lines, including human myeloid leukemia HL-60, liver cancer SMMC-7721, lung cancer A-549, breast cancer MCF-7, and colon cancer SW480 cells .

HY-N0162R

Luteolin (Standard) Maximum Cited Publications 32 Publications Verification Luteoline(Standard); Luteolol(Standard); Digitoflavone (Standard)	Structural Classification Human Gut Microbiota Metabolites Flavonoids other families Classification of Application Fields Source classification Phenols Plants Endogenous metabolite Inflammation/Immunology Disease Research Fields	Keap1-Nrf2 Apoptosis Autophagy Endogenous Metabolite
Luteolin (Standard) is the analytical standard of Luteolin. This product is intended for research and analytical applications. Luteolin (Luteoline), a flavanoid compound, is a potent Nrf2 inhibitor. Luteolin has anti-inflammatory, anti-cancer properties, including the induction of apoptosis and cell cycle arrest, and the inhibition of metastasis and angiogenesis, in several cancer cell lines, including human non-small lung cancer cells .

HY-N10265

Stephacidin B	Alkaloids Microorganisms Classification of Application Fields Source classification Disease Research Fields Alkaloid Dimers Cancer	Endogenous Metabolite
Stephacidin B is a fungal metabolite. Stephacidin B shows in vitro cytotoxicity against a panel of human tumor cell lines. Stephacidin B shows the strongest cytotoxicity against testosterone-dependent prostate LNCaP cancer cells .

HY-123298

Chrysotoxine	Structural Classification Monophenols Orchidaceae Source classification Phenols Plants Dendrobium pulchellum Roxb. et Lindl. :Lindl.	Src Akt Apoptosis
Chrysotoxine is a dual inhibitor of Src/Akt. Chrysotoxine suppresses cancer stem cells (CSCs) phenotypes by down-regulating Src/Akt signaling. Chrysotoxine reduces cell viability and increases apoptosis level in H460 and H23 cells instead of non-tumor cell lines. Chrysotoxine shows rapid excretion and low bioavailability in rats. Chrysotoxine is used in cancer research .

HY-N2081

Skimmianine 1 Publications Verification	Alkaloids Classification of Application Fields Skimmia reevesiana Fort. Source classification Rutaceae Quinoline Alkaloids Plants Disease Research Fields Inflammation/Immunology	Others
Skimmianine is a furoquinoline alkaloid present mainly in the Rutaceae family, with antispastic, anti-inflammatory activities and antiplatelet aggregation effect. Skimmianine exhibits cytotoxicity against a variety of cancer cell lines and genotoxicity .

HY-121199

Germanicol	Triterpenes Structural Classification Euphorbia boetica Terpenoids Source classification Euphorbiaceae Plants	Apoptosis
Germanicol is a selective antineoplastic agent against human colon cancer cell lines HCT-116 and HT29 . Germanicol induces apoptosis via chromatin condensation and DNA damage .

HY-N3451

Isothymusin	Structural Classification Flavonoids Classification of Application Fields Flavones Labiatae Source classification Balsamorhiza macrophylla Nutt. Plants Disease Research Fields Cancer	Lipoxygenase
Isothymusin is a potent anti-oxidant agent. Isothymusin shows radical scavenging activities. Isothymusin shows anti-proliferative activities in cancer cell lines. Isothymusin inhibited the enzymes associated with the promotion stage of cancer, including cycloxygenase- 2 and lipoxygenase-5 .

HY-N6997

Ceratamine A	Alkaloids Classification of Application Fields Animals Source classification Disease Research Fields Cancer	Microtubule/Tubulin
Ceratamine A is an antimitotic heterocyclic alkaloid isolated from the marine sponge Pseudoceratina sp., acts as a microtubule-stabilizing agent. Ceratamine A exhibits cytotoxicity against human cancer cell lines .

HY-108692

Enterolactone	Structural Classification Classification of Application Fields Source classification Lignans Phenylpropanoids Endogenous metabolite Disease Research Fields Cancer	Apoptosis Endogenous Metabolite
Enterolactone is a bioactive phenolic metabolite known as a mammalian lignan derived from dietary lignans. Enterolactone has estrogenic properties and anti-breast cancer activity . Enterolactone is a radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosis .

HY-N6990

Anhydrosecoisolariciresinol	other families Classification of Application Fields Source classification Lignans Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Cancer	Others
Anhydrosecoisolariciresinol is from the flower of Wedelia biflora, has anti-tumor activities . Anhydrosecoisolariciresinol decreases the growth of human breast cancer MCF-7 and MDA-MB-231 cell lines .

HY-N9912

Physalin D	Structural Classification Classification of Application Fields Physalis minima Linn. Ketones, Aldehydes, Acids Source classification Plants Solanaceae Disease Research Fields Cancer	Others
Physalin D is isolated from the aerial parts of Physalis angulate. Physalin D displays considerable cytotoxicity against several cancer cell lines, showing IC₅₀ values in the range of d 0.28 to 2.43 microg/mL. Physalin D has the potential for the cancer disease .

HY-N3097

Pellitorine	Alkaloids Classification of Application Fields Source classification Piperaceae Plants Disease Research Fields Biological Pesticide Research Piper nigrum Linn. Cancer Agricultural Research	Others
Pellitorine is a compound isolated from the roots of Piper nigrum. Pellitorine shows strong cytotoxic activities against HL60 and MCT-7 cell lines. Pellitorine has the potential for the research of cancer diseases .

HY-N7205

Glaucocalyxin D	Structural Classification Terpenoids Labiatae Source classification Diterpenoids Plants Solidago virgaurea L.	Others
Glaucocalyxin D is a ent-kauranoid-type diterpenoid that can be isolated from Rabdosia japonica. Glaucocalyxin D shows cytotoxicity against various human tumor cell lines. Glaucocalyxin D can be used for cancer research .

HY-P1940

Maculosin Cyclo(Tyr-Pro)	Alkaloids Monophenols Microorganisms Pyrrole Alkaloids Source classification Phenols Disease Research Fields Cancer	Others
Maculosin is a host-specific phytotoxin for spotted knapweed from Alternaria alternata. Maculosin is a quorum-sensing molecule involved in cell-cell communication by Pseudomonas aeruginosa. Maculosin also acts as a signaling molecule regulating virulence gene expression in Lactobacillus reuteri. Maculosin shows antioxidant, anti-cancer and non-toxicity properties. Maculosin shows cytotoxic activity against the human liver cancer cell lines, with an IC₅₀ of 48.90 µg/mL .

HY-N9172

Eupaglehnin C	Structural Classification Terpenoids Sesquiterpenes Source classification Erythrina poeppigiana Plants Compositae	Others
Eupaglehnin C is a germacrane-type sesquiterpenoi. Eupaglehnin C can be isolated from the MeOH extract of Eupatorium glehni (Compositae). Eupaglehnin C has cytotoxic activity against HeLa-S3 cancer cell lines .

HY-N10351

27-O-(tert-Butyldimethylsilyl)withaferin A	Classification of Application Fields Source classification Withania somnifera Plants Solanaceae Disease Research Fields Steroids Cancer	Apoptosis
27-O-(tert-Butyldimethylsilyl)withaferin A (compound 9a), a natural withanolide, is an apoptosis inducer. 27-O-(tert-Butyldimethylsilyl)withaferin A shows antiproliferative activity against HeLa, A-549 and MCF-7 human cancer cell lines, and against normal Vero cells .

HY-N2906

Limonianin Atalantoflavone	Structural Classification Flavonoids Flavones Source classification Rutaceae Atalantia buxifolia (Poir.) Oliv. Plants	Parasite
Limonianin (Atalantoflavone) is a flavone, that can be isolated from Erythrina sigmoidea and the root bark of Citrus limonia. Limonianin presents inhibitory effect against P. gingivalis. Limonianin shows cytotoxic activity against multidrug-resistant (MDR) cancer cell lines .

HY-N12200

Mollicellin I	Structural Classification Natural Products Microorganisms Source classification	Others
Mollicellin I (compound 1) is a depsidone. The growth inhibitory activity of Mollicellin I on human breast cancer (Bre04), human lung (Lu04) and human neuroma (N04) cell lines is not significant, with GI₅₀s >10 μg/mL .

HY-N0255

alpha-Hederin α-Hederin	Triterpenes Hedera nepalensis K. Koch var. sinensis (Tobl.) Rehd. Classification of Application Fields Terpenoids Source classification Other Diseases Plants Disease Research Fields Araliaceae	Apoptosis
alpha-Hederin (α-Hederin), a monodesmosidic triterpenoid saponin, exhibits promising antitumor potential against a variety of human cancer cell lines. alpha-Hederin could inhibit the proliferation and induce apoptosis of gastric cancer accompanied by glutathione decrement and reactive oxygen species generation via activating mitochondrial dependent pathway .

HY-N6611

Chimaphilin	Quinones Structural Classification Passifloraceae Source classification Passiflora incarnata L. Plants Naphthalene Quinones	IGF-1R
Chimaphilin is an IGF-1R inhibitor (IC₅₀: 0.086 μM). Chimaphilin has antifungal, antioxidant and anticancer activities. Chimaphilin inhibits the growth of both drug-sensitive and drug-resistant osteosarcoma cell lines. Chimaphilin can induce cancer cell apoptosis. Chimaphilin is a main component of pyrola .

HY-N1261

Scutebarbatine B	Alkaloids Classification of Application Fields Labiatae Source classification Derris robusta Pyridine Alkaloids Plants Disease Research Fields Cancer	Others
Scutebarbatine B shows significant cytotoxic activities against three human cancer lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, with IC₅₀ values in the range 3.5-8.1 mM ^[1]<

HY-120607

Chevalone C	Infection Triterpenes Microorganisms Classification of Application Fields Terpenoids Source classification Disease Research Fields	Parasite
Chevalone C, a meroterpenoid fungal metabolite, shows antimalarial activity with IC₅₀ value of 25.00 μg/mL. Chevalone C has anti-proliferative activity on colon HCT116, liver HepG2 and melanoma A375 cancer cell lines .

HY-N8375

Sieboldin	Structural Classification Source classification Balanophora involucrata Hook. f. Plants Balanophoraceae Saccharides Monosaccharides	Others
Sieboldin is a dihydrochalcone, which inhibits the production of advanced glycation end products (AGE) produced by bovine serum albumins (BSA), has free radical scavenging activity and cytotoxicity in cancer cell lines, and is also used to capture of methylglyoxal (MGO) from Malus baccata .

HY-125664

Lucialdehyde B	Triterpenes Structural Classification Microorganisms Classification of Application Fields Terpenoids Disease Research Fields Cancer	Antibiotic
Lucialdehyde B is a tetracyclic triterpene isolated from the substrates of Ganoderma lucidum with antiviral and cytotoxic activities. Lucialdehyde B has cytotoxic effects against Lewis lung cancer (LLC), T-47D, Sarcoma 180 and Meth-A tumor cell lines .

HY-W663230

Eugenitin	Structural Classification Natural Products Microorganisms Source classification	Parasite
Eugenitin is a polyketide isolated from the fungus Mycoleptodiscus indicus that is related to the South American medicinal plant. Eugenitin inhibits Leishmania major with LD₅₀=39.9 μM. Eugenitin has low cytotoxicity (IC₅₀ >131 μM) against several human cancer cell lines .

HY-N0446

10-Methoxycamptothecin	Alkaloids Structural Classification Classification of Application Fields Source classification Quinoline Alkaloids Camptotheca acuminata Decne. Plants Nyssaceae Disease Research Fields Cancer	ADC Cytotoxin
10-Methoxycamptothecin is a natural bioactive derivative of camptothecin (CPT) isolated from Camptotheca acuminata, and has been confirmed to possess high anti-cancer properties. 10-Methoxycamptothecin has higher cytotoxicity than 10-hydroxycamptothecin by testing antitumor activity against 2774 cell lines .

HY-N10777

1-Ketoaethiopinone	Structural Classification Ardisia crenata Sims Terpenoids Source classification Diterpenoids Plants Myrsinaceae	Others
1-Ketoaethiopinone is an abietane-diterpenoid. 1-Ketoaethiopinone has an α, β-unsaturated carbonyl function. 1-Ketoaethiopinone shows cytotoxic activity against human cancer cell lines MOLT-4 (human lymphoblastic leukemia) and MCF-7 (human breast adenocarcinoma) .

HY-N2132

Flavokawain B 1 Publications Verification Flavokavain B	Flavonoids Chalcones Monophenols other families Classification of Application Fields Source classification Phenols Plants Disease Research Fields Cancer	Apoptosis
Flavokawain B (Flavokavain B) is a chalcone isolated from the root extracts of kava-kava plant and a potent apoptosis inducer for inhibiting the growth of various cancer cell lines. Flavokawain B (Flavokavain B) shows strong antiangiogenic activity. Flavokawain B (Flavokavain B) inhibits human brain endothelial cell (HUVEC) migration and tube formation with very low and non-toxic concentrations .

HY-N4286

4-Methyldaphnetin	other families Classification of Application Fields Source classification Coumarins Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Cancer	Apoptosis
4-Methyldaphnetin is a precursor in the synthesis of derivatives of 4-methyl coumarin. 4-Methyldaphnetin has potent, selective anti-proliferative and apoptosis-inducing effects on several cancer cell lines. 4-Methyldaphnetin possesses radical scavenging property and strongly inhibits membrane lipid peroxidation .

HY-113319

β-D-Fructose	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Saccharides Monosaccharides Cancer	Endogenous Metabolite
β-D-Fructose is a β-fruit sugar that can be produced by the hydrolysis of sucrose. β-D-Fructose can be used as a sweetness potentiator. β-D-Fructose can be designed as a units of antiproliferative agents against breast (MCF-7) and colon (MDST8) cancer cell lines .

HY-N1243

Tubulysin B	Structural Classification Monophenols Microorganisms Classification of Application Fields Source classification Phenols Disease Research Fields Cancer	Microtubule/Tubulin Apoptosis
Tubulysin B is a highly cytotoxic peptide and potent microtubule destabilizing agents isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin B has IC₅₀ values in the picomolar range against many cancer cell lines, including those with multidrug resistant properties .Tubulysin B is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N5152

(2′S)-4′-O-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranosylvisamminol	Monophenols Classification of Application Fields Ophryosporus axilliflorus Hieron. Ketones, Aldehydes, Acids Source classification Phenols Plants Umbelliferae Disease Research Fields Cancer	Others
(2′S)-4′-O-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranosylvisamminol is a chromone Glycoside that could be isolated from Roots of Saposhnikovia divaricate. (2′S)-4′-O-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranosylvisamminol exhibits weak anti-cancer activity in human cancer cell lines .

HY-N0367

Trans-Anethole 1 Publications Verification (E)-Anethole	Classification of Application Fields Simple Phenylpropanols Callicarpa maingayi King & Gamble Source classification Phenylpropanoids Plants Umbelliferae Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
Trans-Anethole ((E)-Anethole), a phenylpropene derivative isolated from Foeniculum vulgare, shows estrogenic activity at lower concentrations and cytotoxic at higher concentrations in cancer cell lines . Trans-Anethole ((E)-Anethole) contributes a large component of the odor and flavor of anise and fennel, anise myrtle, liquorice, camphor, magnolia blossoms, and star anise .

HY-N2584A

Isoxanthohumol 1 Publications Verification	Infection Flavonoids Classification of Application Fields Anti-aging Humulus lupulus L. Flavonones Source classification Plants Moraceae Disease Research Fields Cancer	HSV
Isoxanthohumol is a prenylflavonoid from hops and beer. Isoxanthohumol exhibits an antiproliferative activity against several human cancer cell lines. Isoxanthohumol inhibits the development of lung metastatic foci in tumor-challenged animals. Isoxanthohumol shows an antiviral activity towards herpes viruses (HSV1 and HSV2) and bovine viral diarrhea virus (BVDV) .

HY-N10876

8-epi-Chlorajapolide F	Structural Classification Terpenoids Orchidaceae Sesquiterpenes Source classification Chloranthaceae Plants	Others
8-epi-Chlorajapolide F (compound 1) a sesquiterpene that can be isolated from the aboveground part of the Chloranthus japonicus. 8-epi-Chlorajapolide has few cytotoxic to human cancer cell lines NCI-H460 and SMMC-7721 (IC₅₀s>50 μg/mL) .

Cat. No.	Product Name	Chemical Structure

HY-108692S

Enterolactone-d6
Enterolactone-d₆ is the deuterium labeled Enterolactone. Enterolactone is a bioactive phenolic metabolite known as a mammalian lignan derived from dietary lignans. Enterolactone has estrogenic properties and anti-breast cancer activity[1]. Enterolactone is a radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosis[2].

HY-B0114S1

Oxcarbazepine-d4-1
Oxcarbazepine-d₄-1 is deuterium labeled Oxcarbazepine. Oxcarbazepine is a sodium channel blocker[1]. Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines[2]. Anti-cancer and anticonvulsant effects[2][3].

HY-B0114S

Oxcarbazepine-D4
Oxcarbazepine-d₄ (GP 47680-D4) is the deuterium labeled Oxcarbazepine. Oxcarbazepine is a sodium channel blocker[1]. Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines[2]. Anti-cancer and anticonvulsant effects[2][3].

HY-B0114S2

Oxcarbazepine-d8-1
Oxcarbazepine-d8-1 is a deuterium of Oxcarbazepine. Oxcarbazepine is a sodium channel blocker . Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines . Oxcarbazepine? has anti-cancer and anticonvulsant effects .

HY-19822S2

Elacestrant-d10
Elacestrant-d₁₀ is the deuterium labeled of Elacestrant (HY-19822). Elacestrant is an orally available and selective estrogen receptor degrader (SERD) with IC₅₀s of 48 and 870 nM for ERα and ERβ, respectively. Elacestrant also inhibits growth of ER ⁺ breast cancer cell lines in vitro and in vivo .

HY-19822S

Elacestrant-d4
Elacestrant-d₄ (RAD1901-d₄) is deuterated labeled Elacestrant (HY-19822) Elacestrant (RAD1901) is an orally available and selective estrogen receptor degrader (SERD) with IC₅₀s of 48 and 870 nM for ERα and ERβ, respectively. Elacestrant also can inhibit growth of ER ⁺ breast cancer cell lines in vitro and in vivo.

HY-19822S3

Elacestrant-d6
Elacestrant-d₆ (RAD1901-d₆) is deuterated labeled Elacestrant (HY-19822) Elacestrant (RAD1901) is an orally available and selective estrogen receptor degrader (SERD) with IC₅₀s of 48 and 870 nM for ERα and ERβ, respectively. Elacestrant also can inhibit growth of ER ⁺ breast cancer cell lines in vitro and in vivo.

HY-12033S2

2-Methoxyestradiol-d5

2-Methoxyestradiol-d₅ is the deuterium labeled 2-Hydroxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa[1][2][3][4][5][6][7].

HY-12033S

2-Methoxyestradiol-13C,d3

2-Methoxyestradiol- ¹³C,d₃ is the ¹³C- and deuterium labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa[1][2][3][4][5][6].

HY-12033S1

2-Methoxyestradiol-13C6

2-Methoxyestradiol- ¹³C₆ is the ¹³C-labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa[1][2][3][4][5][6].

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